Michele Zagnoni's research is based on the development of new microsystems for basic biology investigation, diagnosis and treatment of disease using microfluidic and lab-on-a-chip technologies. More information on: www.zagnonilab.com
We use microfluidic and lab-on-a-chip technologies for the development of screening and diagnostic systems for healthcare applications, including fundamental biological research, drug screening and precision medicine, for the creation of in vitro models, organ-on-a-chip and for synthetic biology applications.

• 3D micro-liver on a chip
• Development of microfluidic high-throughput bioassays based on 3D matrix-supported spheroids
• LOC platform for HTS of anti-cancer therapeutics and delivery agents in prostate cancer
• A microfluidics based drug screening platform for human tau mutation neurons
• Developing microfluidic systems for high-throughput studies of functional neuronal networks
• Developing an assay to measure neuron-to-neuron spread of α-synuclein pathology on a microfluidics platform
• Development of a microfluidic assay to study migration of cells essential for remyelination in MS lesions
• Droplet-based Microfluidic Platform for Intracellular Ion Channel Drug Discovery
• Improving cancer cell death using Raman spectroscopy and microfluidic technology
• Feasibility study to use enhanced fluorescent imaging and microfluidic technology for high-throughput drug screening of patient derived tumour cell models

• C. MacKerron, G. Robertson, M. Zagnoni & T. J. Bushell, “A Microfluidic Platform for the Characterisation of CNS Active Compounds”, Sci. Rep., 2017, 7, 15692. DOI:10.1038/s41598-017-15950-0
• K. S. McMillan, A. G. McCluskey, A. Sorensen, M. Boyd & M. Zagnoni, “Emulsion Technologies for Multicellular Tumour Spheroid Radiation Assays”, Analyst, 2016, 141, 100-110. DOI:10.1039/C5AN01382H
• C. A. Cunha-Matos, O. R. Millington, A. W. Wark & M. Zagnoni, “Real-time assessment of nanoparticle-mediated antigen delivery and cell response”, Lab Chip, 2016, 16, 3371-3381. DOI:10.1039/C6LC00599C
• B. Schlicht, M. Zagnoni, “Droplet-interface-bilayer assays in microfluidic passive networks”, Sci. Rep. 2015, 5, 9951. DOI:10.1038/srep09951